Pharmacogenomics

Pharmacogenomics is the study of the genome in drug response.  It investigates the impact of acquired and inherited genetic variation on drug response in patients by connecting gene expression or single-nucleotide polymorphisms with pharmacokinetics and pharmacodynamics. There are several identified genes that are significantly responsible for differences in medication metabolism and response. For the sake of brevity, the focus of this article will concentrate on the genes that are more frequently recognised and used clinically. They are Cytochrome P450s, VKORC1, and TPMT. Patient genotypes are typically classified as Ultra-rapid metabolizer, Extensive metabolizer, Intermediate metabolizer, or Poor metabolizer. Pharmacogenomics could help to limit the occurrence of polypharmacy. It is hoped that with personalised medicinal therapies, patients will not need to take multiple medications to treat the same ailment. Toxicogenomics is a branch of pharmacology that deals with the collecting, interpretation, and preservation of information about gene and protein activity inside a specific cell or tissue of an organism in response to toxic chemical exposure.

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