Dr. Elteleb Gafer Elnaim Abdullah
Nile University, Sudan
Title: Association of Thrombocytopenia, Urine Malaria Antigens, and Blood Groups with Malaria Parasite Density among Sudanese Malaria Patients at Sharg Al-Nile District in Khartoum State
Biography
Biography: Dr. Elteleb Gafer Elnaim Abdullah
Abstract
Background: The malaria parasite (sporozoite) infect a human after biting by infected female anopheles mosquito, the erythrocyte which develop of normoblast finally developed to mature erythrocytes, the malaria parasites (P. falciparum and P. vivax ) most common endemically in Khartoum. Aim: A study was aimed to investigate the association of malaria parasite density with three biomarkers (thrombocytopenia, urine malaria antigens, and ABO & RhD groups).
Methods: A gold standard thick blood film to demonstrate a malaria stained using Gaimsa stain, a density of malaria expressed by number of crosses, then by immune-chromatography test (ICT) to detect malaria antigens according to species from urine deposit, the platelets was estimated by automated haematology analyser (Sysmex KX21 & Mindray) and peripheral blood picture to assess and confirm the platelets count, the ABO and RhD were detected using simple slid method and direct tube method to confirm results, the data were analyzed using SPSS version 22 and the statistical significant was expressed in P value < 0.05. Results: In 63 malaria patients with irrespective to age, the density of malaria parasite show 39 (+), 16 (++) and 8 (+++) respectively, there were significant associations of malaria parasite density (+++) with thrombocytopenia and urine malaria antigens P. value 0.000, 0.004 respectively and insignificancy in (ABO & RhD) and malaria parasite density the P. value 0.959.
Conclusion: A present finding explicit both thrombocytopenia, and urine malaria antigens may associate with high malaria parasite density, but insignificancy association of ABO, RhD phenotypes with density of malaria parasites.