Adaptive Trial Model

clinical trial that assesses a medical device or treatment by potentially observing additional factors, such as side effects, on a set schedule and modifying the trial's protocol's parameters in response to those findings is referred to as an adaptive clinical trial. According to the trial protocol, the adaption process often lasts the entire trial. Included are modified dosage, sample size, a medicine that is being tested, and patient selection criteria. As more knowledge is gathered, trials turn into an ongoing process that regularly adds medicines and patient groups. Prior to the start of the experiment, the protocol establishes the processes and timeframe for adaption.

  • Estimating treatment effects
  • Trial planning
  • Maintaining trial conduct and integrity

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